Human Protein C Activated Purified from Innovative Research has been prepared from Protein C by activation with purified thrombin, which is then removed using ion exchange chromatography. This is a frozen liquid buffered in 20 mM Tris-HCl/0.1 M NaCl/ pH 7.4, with a concentration of 1mg/ml. Complete activation observed by SDS-PAGE analysis.

Also known as Factor XIV, Protein C is a zymogen that, when activated, helps to regulate anticoagulation, inflammation, and more. Key to this process is the ability of Activated Protein C (in conjunction with cofactors) to inactivate Factor Va and Factor VIIIa. Protein C is activated by Thrombin, and can be down-regulated by reduction in EPCR and/or thrombomodulin (either of which can be triggered by inflammatory cytokines) and may be up-regulated by Platelet Factor 4. Protein C is inhibited by Protein C Inhibitor.

More Details:

• Source: Human Plasma
• Purification: Protein C was activated using purified Thrombin, which was then removed using ion exchange chromatography.
• Purity: Complete activation observed on SDS-PAGE
• Storage Conditions: -60 to -80C

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Please note – this product replaces our old product number IAPC (same product, new number).